You will get all kinds of opinions on this and im sure none of them will be wrong. My strike is always set at 45#, often I'm over that after hooking up. If im not trolling my drag lever is backed off to 25#. Once I hook up I go right to strike position. Couple of things to consider. These fish heat up during the fight. The shorter the fight the less likely hood of line chafe. They respond only to pressure. Fighting them on light drag will increase the amount of time it takes to land the fish. After 45 minutes your burning fat. Think about where the fishes head is the entire time your hooked up. The guy running the boat has a lot to do with the length of the fight. Fight the fish in gear.Use the boat to constantly turn the fishes head. I will give you a couple of examples. When the fish runs you let it run. When they are not running is where you get even. Fish often will try to swim parallel to the boat when your in gear. Don't let it. Turn your boat away from the fish. You just put your stern against the fish and his head will have to turn toward the boat because of the pressure you just applied by the change in direction. Constantly turn the boat to control the fish, forcing the head to go places that make it harder for the fish to swim where it wants to. Another example is when the fish is directly under the boat straight up and down. Big fish will often be directly straight under the boat. Very hard to move the fish up when the tail is above the head and they are powering down with that big tail and all that weight. You can spend a lot of time trying to get it up with the rod. All you have to do is corkscrew the boat in a constant tight circle, increase your rpms, and the fish will have no choice but to come up. After a few minutes of positioning the boat in a tight fast circle, the head will move above the tail and as soon as that happens it will come right up to the surface in a pretty tight corkscrew. Drag is just one piece of the puzzle.